Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by a progressive loss of lower motor neurons in the spinal cord. The incretin hormone, glucagon-like peptide-1 (GLP-1), facilitates insulin signaling, and the long acting GLP-1 receptor agonist exendin-4 (Ex...

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Main Authors: Li, Yazhou, Chigurupati, Srinivasulu, Holloway, Harold W., Mughal, Mohamed, Tweedie, David, Bruestle, Daniel A., Mattson, Mark P., Wang, Yun, Harvey, Brandon K., Ray, Balmiki, Lahiri, Debomoy K., Greig, Nigel H.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285661/
https://ncbi.nlm.nih.gov/pubmed/22384126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032008
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