A P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis

Heterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active Gαβγ heterotrimer relies on nucleotide cycling by the Gα subunit: exchange of GTP for GDP activates Gα, where...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bosch, Dustin E., Willard, Francis S., Ramanujam, Ravikrishna, Kimple, Adam J., Willard, Melinda D., Naqvi, Naweed I., Siderovski, David P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285607/
https://ncbi.nlm.nih.gov/pubmed/22383884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002553
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