The Invasive Capacity of HPV Transformed Cells Requires the hDlg-Dependent Enhancement of SGEF/RhoG Activity

A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear. Using a proteomic approach we show that a strong interacting partner of hDlg is the RhoG-specific guanine nucleotide excha...

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Bibliographic Details
Main Authors: Krishna Subbaiah, Vanitha, Massimi, Paola, Boon, Siaw Shi, Myers, Michael P., Sharek, Lisa, Garcia-Mata, Rafael, Banks, Lawrence
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285591/
https://ncbi.nlm.nih.gov/pubmed/22383878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002543
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