Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition

Glycerol-3-phosphate acyltransferase-1 (GPAT1), which is located on the outer mitochondrial membrane comprises up to 30% of total GPAT activity in the heart. It is one of at least four mammalian GPAT isoforms known to catalyze the initial, committed, and rate limiting step of glycerolipid synthesis....

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Main Authors: Lewin, Tal M., de Jong, Hendrik, Schwerbrock, Nicole J. M., Hammond, Linda E., Watkins, Steven M., Combs, Terry P., Coleman, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285559/
https://ncbi.nlm.nih.gov/pubmed/18522808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2008.05.001
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