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Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions

Tumor-initiating cells have been suggested to be rare in many cancers. We tested this in mouse malignant peripheral nerve sheath tumors (MPNSTs) and found that 18% of primary and 49% of passaged MPNSTs cells from Nf1(+/−);Ink4a/Arf(−/−) mice formed tumors upon transplantation whereas only 1.8% to 2....

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Detalhes bibliográficos
Main Authors: Buchstaller, Johanna, McKeever, Paul E., Morrison, Sean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285409/
https://ncbi.nlm.nih.gov/pubmed/22340596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.027
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