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Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions
Tumor-initiating cells have been suggested to be rare in many cancers. We tested this in mouse malignant peripheral nerve sheath tumors (MPNSTs) and found that 18% of primary and 49% of passaged MPNSTs cells from Nf1(+/−);Ink4a/Arf(−/−) mice formed tumors upon transplantation whereas only 1.8% to 2....
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285409/ https://ncbi.nlm.nih.gov/pubmed/22340596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.027 |
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