Trinucleotide Repeat Containing 6a (Tnrc6a)-mediated MicroRNA Function Is Required for Development of Yolk Sac Endoderm

Tnrc6 family members (Tnrc6a/b/c) are key components of the RNA-induced silencing complex in microRNA (miRNA)-mediated gene suppression. Here, we show that Tnrc6a, also known as GW182, is selectively expressed in the yolk sac endoderm and that gene trap disruption of GW182 leads to growth arrest and...

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Autors principals: Jiang, Zhihua, Yu, Nan, Kuang, Pingping, Chen, Melody, Shao, Fengzhi, Martin, Gregory, Chui, David H. K., Cardoso, Wellington V., Ai, Xingbin, Lü, Jining
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285365/
https://ncbi.nlm.nih.gov/pubmed/22187428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.297937
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