Catalytic Mechanism of Sep-tRNA:Cys-tRNA Synthase: SULFUR TRANSFER IS MEDIATED BY DISULFIDE AND PERSULFIDE

Sep-tRNA:Cys-tRNA synthase (SepCysS) catalyzes the sulfhydrylation of tRNA-bound O-phosphoserine (Sep) to form cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) in methanogens that lack the canonical cysteinyl-tRNA synthetase (CysRS). A crystal structure of the Archaeoglobus fulgidus SepCysS apoenzyme provides in...

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Bibliografske podrobnosti
Main Authors: Liu, Yuchen, Dos Santos, Patricia C., Zhu, Xiang, Orlando, Ron, Dean, Dennis R., Söll, Dieter, Yuan, Jing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285321/
https://ncbi.nlm.nih.gov/pubmed/22167197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313700
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