c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G

The neutrophil-derived serine protease, cathepsin G (Cat.G), has been shown to induce myocyte detachment and apoptosis by anoikis through down-regulation of focal adhesion (FA) signaling. However, the mechanisms that control FA protein stability and turnover in myocytes are not well understood. Here...

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Bibliographic Details
Main Authors: Rafiq, Khadija, Guo, Jianfen, Vlasenko, Liudmila, Guo, Xinji, Kolpakov, Mikhail A., Sanjay, Archana, Houser, Steven R., Sabri, Abdelkarim
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285313/
https://ncbi.nlm.nih.gov/pubmed/22203672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.307009
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