Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein

BACKGROUND: Modified Vaccinia Ankara (MVA) is an attenuated strain of Vaccinia virus (VACV) currently employed in many clinical trials against HIV/AIDS and other diseases. MVA still retains genes involved in host immune response evasion, enabling its optimization by removing some of them. The aim of...

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Bibliografiske detaljer
Main Authors: Falivene, Juliana, Del Médico Zajac, María Paula, Pascutti, María Fernanda, Rodríguez, Ana María, Maeto, Cynthia, Perdiguero, Beatriz, Gómez, Carmen E., Esteban, Mariano, Calamante, Gabriela, Gherardi, María Magdalena
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285208/
https://ncbi.nlm.nih.gov/pubmed/22384183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032220
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