Systematic Evaluation of the Metabolic to Mitogenic Potency Ratio for B10-Substituted Insulin Analogues

BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much scrutiny and debate. However, B10 is still an attra...

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Main Authors: Glendorf, Tine, Knudsen, Louise, Stidsen, Carsten E., Hansen, Bo F., Hegelund, Anne Charlotte, Sørensen, Anders R., Nishimura, Erica, Kjeldsen, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285154/
https://ncbi.nlm.nih.gov/pubmed/22383948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029198
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