L type Ca(2+ )channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats

BACKGROUND: Oxaliplatin is an important drug used in the treatment of colorectal cancer. However, it frequently causes severe acute and chronic peripheral neuropathies. We recently reported that repeated administration of oxaliplatin induced cold hyperalgesia in the early phase and mechanical allody...

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Détails bibliographiques
Auteurs principaux: Kawashiri, Takehiro, Egashira, Nobuaki, Kurobe, Kentaro, Tsutsumi, Kuniaki, Yamashita, Yuji, Ushio, Soichiro, Yano, Takahisa, Oishi, Ryozo
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285049/
https://ncbi.nlm.nih.gov/pubmed/22292988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-7
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