L type Ca(2+ )channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats

BACKGROUND: Oxaliplatin is an important drug used in the treatment of colorectal cancer. However, it frequently causes severe acute and chronic peripheral neuropathies. We recently reported that repeated administration of oxaliplatin induced cold hyperalgesia in the early phase and mechanical allody...

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Autores principales: Kawashiri, Takehiro, Egashira, Nobuaki, Kurobe, Kentaro, Tsutsumi, Kuniaki, Yamashita, Yuji, Ushio, Soichiro, Yano, Takahisa, Oishi, Ryozo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285049/
https://ncbi.nlm.nih.gov/pubmed/22292988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-7
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