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Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish
Mutations in the store-operated Ca(2+) entry pore protein ORAI1 have been reported to cause myopathies in human patients but the mechanism involved is not known. Cardiomyocytes express ORAI1 but its role in heart function is also unknown. Using reverse genetics in zebrafish, we demonstrated that ina...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3283868/ https://ncbi.nlm.nih.gov/pubmed/22302996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.090464 |
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