Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations

The serotonin (5-HT) transporter (SERT) plays an important role in the termination of 5-HT-mediated neurotransmission by transporting 5-HT away from the synaptic cleft and into the presynaptic neuron. In addition, SERT is the main target for antidepressant drugs, including the selective serotonin re...

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Hlavní autoři: Gabrielsen, Mari, Ravna, Aina Westrheim, Kristiansen, Kurt, Sylte, Ingebrigt
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer-Verlag 2011
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283764/
https://ncbi.nlm.nih.gov/pubmed/21670993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00894-011-1133-1
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