Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

BACKGROUND: The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard (125)I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long sample processing times and requires the use of ne...

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Detalhes bibliográficos
Main Authors: Lo, Bernice, Swafford, Austin DE, Shafer-Weaver, Kimberly A, Jerome, Lawrence F, Rakhlin, Luba, Mathern, Douglas R, Callahan, Conor A, Jiang, Ping, Davison, Lucy J, Stevens, Helen E, Lucas, Carrie L, White, Jill, von Borstel, Reid, Todd, John A, Lenardo, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283543/
https://ncbi.nlm.nih.gov/pubmed/22123298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-203
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