Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure

BACKGROUND: Chloroquine resistance (CQR) phenotype in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr-1 genes. Mutations at amino acid position 72-76 of pfcrt gene, here defined as pfcrt haplotype are associated with the geographic origin of chloroquine resistant parasite. Here...

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Autors principals: Mallick, Prashant K, Joshi, Hema, Valecha, Neena, Sharma, Surya K, Eapen, Alex, Bhatt, Rajendra M, Srivastava, Harish C, Sutton, Patrick L, Dash, Aditya P, Bhasin, Virendra K
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283508/
https://ncbi.nlm.nih.gov/pubmed/22236376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-16
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