Inactivation of Tetrahymena rRNA self-splicing by cis-platin proceeds through dissociable complexes.
The anti-cancer drug cis-diamminedichloroplatinum (II) (cis-DDP) reacted with Tetrahymena self-splicing rRNA ribozyme, causing loss of self-splicing activity and formation of a number of platinated RNA species. The formation of one distinct platinated product, migrating at an apparent size of 2400 n...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1991
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| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC328280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1905401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.11.3123 |
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