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Identification of Mammalian Protein Quality Control Factors by High-Throughput Cellular Imaging

Protein Quality Control (PQC) pathways are essential to maintain the equilibrium between protein folding and the clearance of misfolded proteins. In order to discover novel human PQC factors, we developed a high-content, high-throughput cell-based assay to assess PQC activity. The assay is based on...

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Autors principals: Pegoraro, Gianluca, Voss, Ty C., Martin, Scott E., Tuzmen, Pinar, Guha, Rajarshi, Misteli, Tom
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282772/
https://ncbi.nlm.nih.gov/pubmed/22363705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031684
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