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Identification of Mammalian Protein Quality Control Factors by High-Throughput Cellular Imaging

Protein Quality Control (PQC) pathways are essential to maintain the equilibrium between protein folding and the clearance of misfolded proteins. In order to discover novel human PQC factors, we developed a high-content, high-throughput cell-based assay to assess PQC activity. The assay is based on...

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Main Authors: Pegoraro, Gianluca, Voss, Ty C., Martin, Scott E., Tuzmen, Pinar, Guha, Rajarshi, Misteli, Tom
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282772/
https://ncbi.nlm.nih.gov/pubmed/22363705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031684
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