Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells

Heparanase (HPA), an endo-h-D-glucuronidase that cleaves the heparan sulfate chain of heparan sulfate proteoglycans, is overexpressed in majority of human cancers. Recent evidence suggests that small interfering RNA (siRNA) induces transcriptional gene silencing (TGS) in human cells. In this study,...

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Autores principales: Jiang, Guosong, Zheng, Liduan, Pu, Jiarui, Mei, Hong, Zhao, Jun, Huang, Kai, Zeng, Fuqing, Tong, Qiangsong
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282686/
https://ncbi.nlm.nih.gov/pubmed/22363633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031379
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