PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

Poly ADP-ribose polymerase (PARP) is a protein involved in single strand break repair. Recently, PARP inhibitors have shown considerable promise in the treatment of several cancers, both in monotherapy and in combination with cytotoxic agents. Synthetic lethal action of PARP inhibitors has been obse...

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Detalhes bibliográficos
Main Authors: van Vuurden, Dannis G., Hulleman, Esther, Meijer, Olga L.M., Wedekind, Laurine E., Kool, Marcel, Witt, Hendrik, Vandertop, Peter W. Peter, Würdinger, Thomas, Noske, David P., Kaspers, Gertjan J.L., Cloos, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282104/
https://ncbi.nlm.nih.gov/pubmed/22184287
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