PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

Poly ADP-ribose polymerase (PARP) is a protein involved in single strand break repair. Recently, PARP inhibitors have shown considerable promise in the treatment of several cancers, both in monotherapy and in combination with cytotoxic agents. Synthetic lethal action of PARP inhibitors has been obse...

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Bibliographische Detailangaben
Hauptverfasser: van Vuurden, Dannis G., Hulleman, Esther, Meijer, Olga L.M., Wedekind, Laurine E., Kool, Marcel, Witt, Hendrik, Vandertop, Peter W. Peter, Würdinger, Thomas, Noske, David P., Kaspers, Gertjan J.L., Cloos, Jacqueline
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2011
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282104/
https://ncbi.nlm.nih.gov/pubmed/22184287
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