Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability. The kinesin-13 family is critical in the regulation of microtubule dynamics and the bes...

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Bibliographische Detailangaben
Hauptverfasser: Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda, Louwen, Frank, Yuan, Juping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282097/
https://ncbi.nlm.nih.gov/pubmed/22249213
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