A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA)

We have developed a modular scaffold for preparing high-affinity, homo-multivalent inhibitors of the prostate-specific membrane antigen (PSMA) for imaging and therapy of prostate cancer (PCa). Our system contains a lysine-based (∝-, ε-) dialkyne residue for incorporating a PSMA binding Lys-Glu urea...

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Main Authors: Banerjee, Sangeeta Ray, Pullambhatla, Mrudula, Shallal, Hassan, Lisok, Ala, Mease, Ronnie C., Pomper, Martin G.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2011
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282081/
https://ncbi.nlm.nih.gov/pubmed/22207391
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