Comparisons of the Efficacy of a Jak1/2 Inhibitor (AZD1480) with a VEGF Signaling Inhibitor (Cediranib) and Sham Treatments in Mouse Tumors Using DCE-MRI, DW-MRI, and Histology

Jak1/2 inhibition suppresses STAT3 phosphorylation that is characteristic of many cancers. Activated STAT3 promotes the transcription of factors that enhance tumor growth, survival, and angiogenesis. AZD1480 is a novel small molecule inhibitor of Jak1/2, which is a key mediator of STAT3 activation....

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Main Authors: Loveless, Mary E, Lawson, Deborah, Collins, Michael, Prasad Nadella, Murali V, Reimer, Corinne, Huszar, Dennis, Halliday, Jane, Waterton, John C, Gore, John C, Yankeelov, Thomas E
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281942/
https://ncbi.nlm.nih.gov/pubmed/22355274
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