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TNFα-Induced Apoptosis Enabled by CCN1/CYR61: Pathways of Reactive Oxygen Species Generation and Cytochrome c Release

Although TNFα is a strong inducer of apoptosis, its cytotoxicity in most normal cells in vitro requires blockade of NFκB signaling or inhibition of de novo protein synthesis, typically by the addition of cycloheximide. However, several members of CCN (CYR61/CTGF/NOV) family of extracellular matrix p...

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Detalles Bibliográficos
Main Authors: Juric, Vladislava, Chen, Chih-Chiun, Lau, Lester F.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281933/
https://ncbi.nlm.nih.gov/pubmed/22363611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031303
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