TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

BACKGROUND: T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8(+) T cells in both chronic infection and tumor. However, the nature of TIM-3(+)CD4(+) T cells in the tumor microenvi...

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Detalhes bibliográficos
Main Authors: Gao, Xin, Zhu, Yibei, Li, Gang, Huang, Haitao, Zhang, Guangbo, Wang, Fengming, Sun, Jing, Yang, Qianting, Zhang, Xueguang, Lu, Binfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281852/
https://ncbi.nlm.nih.gov/pubmed/22363469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030676
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