Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms

The Fanconi anemia complementation group A (FANCA) gene is one of 15 disease-causing genes and has been found to be mutated in ∼60% of Fanconi anemia patients. Using purified protein, we report that human FANCA has intrinsic affinity for nucleic acids. FANCA binds to both single-stranded (ssDNA) and...

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Detalhes bibliográficos
Main Authors: Yuan, Fenghua, Qian, Liangyue, Zhao, Xinliang, Liu, Jesse Y., Song, Limin, D'Urso, Gennaro, Jain, Chaitanya, Zhang, Yanbin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281618/
https://ncbi.nlm.nih.gov/pubmed/22194614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315366
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