The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b)

Regulated intramembrane proteolysis is a widely accepted concept describing the processing of various transmembrane proteins via ectodomain shedding followed by an intramembrane cleavage. The resulting cleavage products can be involved in reverse signaling. Presenilins, which constitute the active c...

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Bibliographic Details
Main Authors: Fluhrer, Regina, Martin, Lucas, Klier, Bärbel, Haug-Kröper, Martina, Grammer, Gudula, Nuscher, Brigitte, Haass, Christian
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281599/
https://ncbi.nlm.nih.gov/pubmed/22194595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328104
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