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Glucose Enhances Leptin Signaling through Modulation of AMPK Activity
Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3. The JAK2/STAT3 pathway is required for leptin control of energy balance and body weight. Defects in leptin signaling lead to lep...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281098/ https://ncbi.nlm.nih.gov/pubmed/22359610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031636 |
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