Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein

Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. C...

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Detalhes bibliográficos
Main Authors: Yang, Jia-Ming, Ip, Siu-Po, Xian, Yanfang, Zhao, Ming, Lin, Zhi-Xiu, Yeung, John Hok Keung, Chan, Raphael Chiu Yeung, Lee, Shui-Shan, Che, Chun-Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281083/
https://ncbi.nlm.nih.gov/pubmed/22359586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031312
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