Specific and Sensitive Hydrolysis Probe-Based Real-Time PCR Detection of Epidermal Growth Factor Receptor Variant III in Oral Squamous Cell Carcinoma

BACKGROUND: The tumor-specific EGFR deletion mutant, EGFRvIII, is characterised by ligand-independent constitutive signalling. Tumors expressing EGFRvIII are resistant to current EGFR-targeted therapy. The frequency of EGFRvIII in head and neck squamous cell carcinoma (HNSCC) is disputed and may var...

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Main Authors: McIntyre, John B., Bose, Pinaki, Klimowicz, Alexander C., Brockton, Nigel T., Petrillo, Stephanie, Matthews, Wayne, Easaw, Jay, Magliocco, Anthony, Dort, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280998/
https://ncbi.nlm.nih.gov/pubmed/22359620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031723
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