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Dynamic Energy Landscapes of Riboswitches Help Interpret Conformational Rearrangements and Function

Riboswitches are RNAs that modulate gene expression by ligand-induced conformational changes. However, the way in which sequence dictates alternative folding pathways of gene regulation remains unclear. In this study, we compute energy landscapes, which describe the accessible secondary structures f...

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Bibliografische gegevens
Hoofdauteurs: Quarta, Giulio, Sin, Ken, Schlick, Tamar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280964/
https://ncbi.nlm.nih.gov/pubmed/22359488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002368
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