Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models

BACKGROUND: Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). METHODS: (14)C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing human, rat, or mouse SGLT2 or SGLT1; (3)H-2-deoxy-d-gl...

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Detalhes bibliográficos
Main Authors: Liang, Yin, Arakawa, Kenji, Ueta, Kiichiro, Matsushita, Yasuaki, Kuriyama, Chiaki, Martin, Tonya, Du, Fuyong, Liu, Yi, Xu, June, Conway, Bruce, Conway, Jamie, Polidori, David, Ways, Kirk, Demarest, Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280264/
https://ncbi.nlm.nih.gov/pubmed/22355316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030555
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