Virologic Failures on Initial Boosted-PI Regimen Infrequently Possess Low-Level Variants with Major PI Resistance Mutations by Ultra-Deep Sequencing

BACKGROUND: It is unknown whether HIV-positive patients experiencing virologic failure (VF) on boosted-PI (PI/r) regimens without drug resistant mutations (DRM) by standard genotyping harbor low-level PI resistant variants. CASTLE compared the efficacy of atazanavir/ritonavir (ATV/r) with lopinavir/...

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Autores principales: Lataillade, Max, Chiarella, Jennifer, Yang, Rong, DeGrosky, Michelle, Uy, Jonathan, Seekins, Daniel, Simen, Birgitte, St. John, Elizabeth, Moreno, Elizabeth, Kozal, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280244/
https://ncbi.nlm.nih.gov/pubmed/22355307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030118
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