Prevalence and Clinical Significance of HIV Drug Resistance Mutations by Ultra-Deep Sequencing in Antiretroviral-Naïve Subjects in the CASTLE Study

BACKGROUND: CASTLE compared the efficacy of atazanavir/ritonavir with lopinavir/ritonavir, each in combination with tenofovir-emtricitabine in ARV-naïve subjects from 5 continents. OBJECTIVES: Determine the baseline rate and clinical significance of TDR mutations using ultra-deep sequencing (UDS) in...

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Hauptverfasser: Lataillade, Max, Chiarella, Jennifer, Yang, Rong, Schnittman, Steven, Wirtz, Victoria, Uy, Jonathan, Seekins, Daniel, Krystal, Mark, Mancini, Marco, McGrath, Donnie, Simen, Birgitte, Egholm, Michael, Kozal, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880604/
https://ncbi.nlm.nih.gov/pubmed/20532178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010952
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