Identification of Novel Small Molecule Activators of Nuclear Factor-κB With Neuroprotective Action Via High-Throughput Screening

Neuronal noncytokine-dependent p50/p65 nuclear factor-κB (the primary NF-κB complex in the brain) activation has been shown to exert neuroprotective actions. Thus neuronal activation of NF-κB could represent a viable neuroprotective target. We have developed a cell-based assay able to detect NF-κB e...

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Detalhes bibliográficos
Main Authors: Manuvakhova, Marina S., Johnson, Guyla G., White, Misti C., Ananthan, Subramaniam, Sosa, Melinda, Maddox, Clinton, McKellip, Sara, Rasmussen, Lynn, Wennerberg, Krister, Hobrath, Judith V., White, E. Lucile, Maddry, Joseph A., Grimaldi, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280078/
https://ncbi.nlm.nih.gov/pubmed/21046675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22526
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