Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, That Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy

[Image: see text] The discovery of upregulated glycogen synthase kinase-3 (GSK-3) in various pathological conditions has led to the development of a host of chemically diverse small molecule GSK-3 inhibitors, such as BIP-135. GSK-3 inhibition emerged as an alternative therapeutic target for treating...

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Autores principales: Chen, Po C., Gaisina, Irina N., El-Khodor, Bassem F., Ramboz, Sylvie, Makhortova, Nina R., Rubin, Lee L., Kozikowski, Alan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2011
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279955/
https://ncbi.nlm.nih.gov/pubmed/22348181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200085z
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