AMPK Potentiates Hypertonicity-induced Apoptosis by Suppressing NFκB/COX-2 in Medullary Interstitial Cells

Cells residing in the hypertonic, hypoxic renal medulla depend on dynamic adaptation mechanisms to respond to changes in energy supply and demand. The serine/threonine kinase 5′-AMP protein kinase (AMPK) is a sensor of cellular energy status, but whether it contributes to the survival of cells in th...

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Bibliografiske detaljer
Main Authors: Han, Qifei, Zhang, Xiaoyan, Xue, Rui, Yang, Hang, Zhou, Yunfeng, Kong, Xiaomu, Zhao, Pan, Li, Jing, Yang, Jichun, Zhu, Yi, Guan, Youfei
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2011
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279950/
https://ncbi.nlm.nih.gov/pubmed/21903993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010080822
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