Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

OBJECTIVE: The contribution of mitochondrial dysfunction to skeletal muscle insulin resistance remains elusive. Comparative proteomics are being applied to generate new hypotheses in human biology and were applied here to isolated mitochondria to identify novel changes in mitochondrial protein abund...

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Detalhes bibliográficos
Main Authors: Lefort, Natalie, Glancy, Brian, Bowen, Benjamin, Willis, Wayne T., Bailowitz, Zachary, De Filippis, Elena A., Brophy, Colleen, Meyer, Christian, Højlund, Kurt, Yi, Zhengping, Mandarino, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279558/
https://ncbi.nlm.nih.gov/pubmed/20682693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0174
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