Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

OBJECTIVE: The contribution of mitochondrial dysfunction to skeletal muscle insulin resistance remains elusive. Comparative proteomics are being applied to generate new hypotheses in human biology and were applied here to isolated mitochondria to identify novel changes in mitochondrial protein abund...

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Main Authors: Lefort, Natalie, Glancy, Brian, Bowen, Benjamin, Willis, Wayne T., Bailowitz, Zachary, De Filippis, Elena A., Brophy, Colleen, Meyer, Christian, Højlund, Kurt, Yi, Zhengping, Mandarino, Lawrence J.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2010
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279558/
https://ncbi.nlm.nih.gov/pubmed/20682693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0174
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