Unexpected Acceleration of Type 1 Diabetes by Transgenic Expression of B7-H1 in NOD Mouse Peri-Islet Glia

OBJECTIVE: Autoimmune target tissues in type 1 diabetes include pancreatic β-cells and peri-islet Schwann cells (pSC)—the latter active participants or passive bystanders in pre-diabetic autoimmune progression. To distinguish between these alternatives, we sought to suppress pSC autoimmunity by tran...

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Main Authors: Yantha, Jason, Tsui, Hubert, Winer, Shawn, Song, Aihua, Wu, Ping, Paltser, Geoff, Ellis, James, Dosch, H.-Michael
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2010
Teme:
Immunology and Transplantation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279538/
https://ncbi.nlm.nih.gov/pubmed/20522597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1209
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