Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1and Gαz

Hyperactivity of hypothalamic-pituitary mediated hormone responses, such as to stimulation with a serotonin 1A (5-HT(1A)) receptor agonist, are a feature of depression which are normalized with clinical improvement during drug therapy. We previously reported that SSRIs induce desensitization of 5-HT...

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Bibliographic Details
Main Authors: Creech, RD, Li, Q, Carrasco, GA, Van de Kar, LD, Muma, NA
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278536/
https://ncbi.nlm.nih.gov/pubmed/22251927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.01.001
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