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Rictor regulates FBXW7-dependent c-Myc and cylcin E degradation in colorectal cancer cells
Rictor (Rapamycin-insensitive companion of mTOR) forms a complex with mTOR and phosphorylates and activates Akt. Activation of Akt induces expression of c-Myc and cyclin E, which are overexpressed in colorectal cancer and play an important role in colorectal cancer cell proliferation. Here, we show...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278531/ https://ncbi.nlm.nih.gov/pubmed/22285861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.01.054 |
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