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The Role of GC-Biased Gene Conversion in Shaping the Fastest Evolving Regions of the Human Genome

GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that accelerates the fixation of guanine or cytosine alleles, regardless of their effects on fitness. gBGC can increase the overall rate of substitutions, a hallmark of positive selection. Many fast-evolving genes an...

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Autors principals: Kostka, Dennis, Hubisz, Melissa J., Siepel, Adam, Pollard, Katherine S.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278478/
https://ncbi.nlm.nih.gov/pubmed/22075116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msr279
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