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Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas

Glioblastomas are among the most incurable cancers. Our past findings indicated that glioblastoma cells, but not neurons or glia, require the transcription factor ATF5 (activating transcription factor 5) for survival. However, it was unknown whether interference with ATF5 function can prevent or pro...

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Detalhes bibliográficos
Main Authors: Arias, A, Lamé, M W, Santarelli, L, Hen, R, Greene, L A, Angelastro, J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277917/
https://ncbi.nlm.nih.gov/pubmed/21725368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.276
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