Effect of Single Amino Acid Substitution on Oxidative Modifications of the Parkinson's Disease-Related Protein, DJ-1

Mutations in the gene encoding DJ-1 have been identified in patients with familial Parkinson's disease (PD) and are thought to inactivate a neuroprotective function. Oxidation of the sulfhydryl group to a sulfinic acid on cysteine residue C106 of DJ-1 yields the “2O ” form, a variant of the pro...

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Detalhes bibliográficos
Main Authors: Madian, Ashraf G., Hindupur, Jagadish, Hulleman, John D., Diaz-Maldonado, Naomi, Mishra, Vartika R., Guigard, Emmanuel, Kay, Cyril M., Rochet, Jean-Christophe, Regnier, Fred E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277756/
https://ncbi.nlm.nih.gov/pubmed/22104028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.010892
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