Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

BACKGROUND: Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal models of arthritis and suppress inflammatory cytokine production in rheumatoid arthritis (RA) synovial macrophages and tissue. OBJECTIVES: To determine the molecular mechanisms contributing to the suppr...

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Hauptverfasser: Grabiec, Aleksander M, Korchynskyi, Olexandr, Tak, Paul P, Reedquist, Kris A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Group 2011
Schlagworte:
Basic and Translational Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277722/
https://ncbi.nlm.nih.gov/pubmed/21953341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2011.154211
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