Erythrocyte plasma membrane–bound ERK1/2 activation promotes ICAM-4–mediated sickle red cell adhesion to endothelium

The core pathology of sickle cell disease (SCD) starts with the erythrocyte (RBC). Aberration in MAPK/ERK1/2 signaling, which can regulate cell adhesion, occurs in diverse pathologies. Because RBCs contain abundant ERK1/2, we predicted that ERK1/2 is functional in sickle (SS) RBCs and promotes adher...

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Détails bibliographiques
Auteurs principaux: Zennadi, Rahima, Whalen, Erin J., Soderblom, Erik J., Alexander, Susan C., Thompson, J. Will, Dubois, Laura G., Moseley, M. Arthur, Telen, Marilyn J.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Red Cells, Iron, and Erythropoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277354/
https://ncbi.nlm.nih.gov/pubmed/22147898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-344440
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