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Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression

Polyalanine (poly-A) tracts exist in 494 annotated proteins; to date, expansions in these tracts have been associated with nine human diseases. The pathogenetic mechanism by which a poly-A tract results in these various human disorders remains uncertain. To understand the role of this mutation type,...

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Библиографические подробности
Главные авторы: Nasrallah, MacLean Pancoast, Cho, Ginam, Simonet, Jacqueline C., Putt, Mary E., Kitamura, Kunio, Golden, Jeffrey A.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277309/
https://ncbi.nlm.nih.gov/pubmed/22108177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr538
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