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The Structure of Genealogies in the Presence of Purifying Selection: A Fitness-Class Coalescent

Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be common in nature, our understanding of how we expect purifying selection to affect patterns of molecular variation rema...

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Détails bibliographiques
Auteurs principaux: Walczak, Aleksandra M., Nicolaisen, Lauren E., Plotkin, Joshua B., Desai, Michael M.
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276618/
https://ncbi.nlm.nih.gov/pubmed/22135349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.134544
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